TL;DR
- Statins lower LDL cholesterol and reduce heart attack and stroke risk in appropriate patients.
- Muscle aches are common but often mild; true myopathy and liver injury are rare.
- Discuss drug interactions and lifestyle changes; monitor as guided by local practice.
Who benefits from statins?
People with established ASCVD, LDL above certain thresholds, diabetes with risk factors, or elevated calculated risk may be candidates based on guidelines.
Dosing and intensity
Choice of agent and intensity (low, moderate, high) depends on risk and tolerance. Adherence and lifestyle remain essential.
Adverse effects and interactions
- Myalgias and mild CK elevations are relatively common; severe myopathy is rare. Consider rechallenge, switch, or lower dose if needed.
- Drug interactions vary by statin and metabolism (e.g., CYP3A4). Review the patient’s medication list.
Disclaimer
Informational content only, not medical advice. Follow your clinician’s guidance and local protocols.
References
- AHA/ACC Cholesterol Guidelines. heart.org
- NICE Lipid modification guidance. nice.org.uk