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Pharma.cy

OTC cough and cold: what works (and what doesn’t)

Pharma.cy Editorial Team
Updated 8/18/2025
TL;DR
  • Nasal congestion: intranasal decongestants (short‑term) and saline; oral decongestants offer modest benefit with side effects.
  • Cough: honey (adults/children over 1 year) may help; evidence for many OTCs is mixed.
  • Always check labels to avoid duplicate acetaminophen or antihistamines in combo products.

Symptom‑based approach

  • Fever/aches: consider acetaminophen or ibuprofen as appropriate.
  • Congestion: topical decongestants for up to 3 days to avoid rebound; saline sprays/rinses are safe.
  • Cough: honey, throat lozenges; limited evidence for dextromethorphan or guaifenesin.

Safety cautions

  • Avoid multi‑ingredient products when possible; match treatments to symptoms.
  • Beware of stimulant effects of oral decongestants and drug interactions.
  • Children: follow age restrictions and weight‑based dosing; consult a clinician when unsure.

Disclaimer

Informational only, not medical advice. Follow local products’ labels and consult a clinician if symptoms worsen.

References